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KMID : 0388019930040030071
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Korean Journal Gynecologic Oncology and Colposcopy
1993 Volume.4 No. 3 p.71 ~ p.78
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Combination Chemotherapy for Malignant Ovarian Gerum Cell Tumors
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이민용
이태성/여준규/신혜영/이형종/차순도/서영욱
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Abstract
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Thirteen patients with malignant germ cell tumors of the ovary have been treated with a combination chemotherapy. The age of patients ranged form 11 to 50 years and here was no history of radiation therapy of chemotherapy except operation. Stage
distributions are as follow; 2 patients are stage Ⅳ, 3 are stage Ⅱ and remained 8 are stage I.
4 patients with immature teratoma and 2 patients with mixed germ cell tumor received. VAC chemotherapy, as primary therapy, and among them 1 lost to follow up but remained 5 cases live without evidence of disease 39 to 83 months. There were 3
patients
with endodermal sinus tumor and 1 received VAC and remained 2 received PVB as primary chemotherapy. Of them 1 died of disease after 9 months of operation and the other 2 live now with no evidence of disease.
There were 2 patients with dysgerminoma and 2 with primary ovarian choriocarcinoma. 1 patient with dysgerminoma and 1 with choriocarcinoma were died because of chemotherapy toxicity 1 patient with dysgerminoma, who refused further chemotherapy
after 1
course of chemotherapy, died of progressive disease. 1 patient wit choriocarcinoma now live well without evidence of disease at 35 months. The combination chemotherapy using VAC or PVB regimen represents an effective treatment for malignant germ
cell
tumors of the ovary and reveals moderate toxicity.
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